Limbic Cross-Wiring: Symptoms, Causes, Diagnosis, and Treatment

Limbic Cross-Wiring: Symptoms, Causes, Diagnosis, and Treatment
The limbic system[1] is a group of brain structures that work together and includes the amygdala, hypothalamus, hippocampus, and cingulate cortex . The limbic system acts as a control center for conscious and unconscious functions, regulating much of what the body does. It has several important functions, including:
  • Assigning emotional significance to everything we see, smell, hear, feel, and taste.
  • Driving our primal fight/flight/freeze response, which serves to determine our level of safety and protect us from danger.
  • Forming memories.
  • Regulating hormones.
  • Regulating the parasympathetic and sympathetic nervous systems, which control unconscious body processes, such as pulse, blood pressure, breathing, and arousal in response to physical or emotional circumstances.
  • Regulating functions of internal organs, such as the heart and intestines.
  • Controlling all aspects of emotional and motivational functioning, such as the desire for food, feelings of anger, pain, pleasure, and sexual desire.
  • Working with the immune system to defend against foreign invaders.
Under normal circumstances, the protective mechanisms of the limbic system would only become activated in times of appropriate danger or threat. However, if the limbic system becomes impaired as a result of various forms of trauma[2], it can cause “cross-wiring” of normal neuronal circuits in the brain. Limbic system cross-wiring can cause distorted unconscious reactions, sensory perceptions, and protective responses. Over time, these faulty reactions can become conditioned, resulting in chronic, inappropriate activation of the immune, endocrine, and autonomic nervous systems. This constant activation can lead to numerous, seemingly unconnected symptoms. In this article, we’ll be covering everything you need to know about limbic cross-wiring, including how re-origin, a neuroplasticity-based treatment program, can help you eliminate dysfunctional brain patterns and re-establish health, happiness, and balance.

Symptoms of Limbic Cross-Wiring

Due to the many important functions for which the limbic system is responsible, limbic cross-wiring can result in a number of conditions including: Each of the above conditions has its own distinct set of symptoms, however, many symptoms overlap. Limbic cross-wiring can also cause a number of symptoms that can’t be defined by a specific condition, including (but not limited to):
  • Insomnia
  • Lack of sex drive
  • Latent infections
  • Poor circulation
  • Sensitivity to smell, taste, light, sound, and touch
  • Tinnitus
  • Mood swings
  • Brain fog

Causes and Risk Factors of Limbic Cross-Wiring

Limbic cross-wiring occurs when the limbic system becomes “stuck” in a state of fight or flight. What causes this overactive stress response? It typically occurs when a high chronic stress load[3] combines with an acute infection, injury, or another traumatic event. The stress and acute trauma couple together to form what’s known as a neuroimmune association. This occurs because, as psychologist Donald Olding Hebb said, “Neurons that fire together wire together.” In others words, the brain forms associations when two things occur simultaneously. As an example of this, let’s take a look at a fascinating study. Rats were given an injection of E. coli virus combined with sugar water (or dextrose solution) over and over again. As you would expect, their bodies mounted an immune response to the E. coli virus. Then an interesting thing happened. After several repetitions of this sequence, they were given an injection with just the sugar water (without the virus). Their bodies mounted the exact same immune response, even though no virus was present. These results suggest that the rats’ limbic systems had been conditioned to trigger an immune response when injected with the sugar water. The rats’ brains anticipated the presence of the virus whenever they were injected with sugar water, even though they were no longer being injected with this virus. This study demonstrates how the limbic system can become conditioned to trigger a number of symptoms even in the absence of an actual threat.

How Limbic Cross-Wiring is Diagnosed

While more and more research[4] is pointing to the fact that limbic cross-wiring can cause the symptoms and conditions listed above, that explanation has not yet infiltrated traditional medicine. As such, you’re not likely to be diagnosed with limbic cross-wiring by your family doctor. There are, however, a number of practitioners, especially functional medicine and naturopathic doctors, who are educated on the science and research behind limbic cross-wiring. That being said, limbic cross-wiring is typically self-diagnosed after other causes are ruled out by doctors. If you’re experiencing unusual symptoms, it’s important to get thoroughly evaluated by a doctor to rule out any underlying cause for your symptoms. If after a thorough evaluation a doctor tells you that they can’t find anything “wrong” with you, or they diagnose you with one of the conditions listed above, such as chronic fatigue syndrome, fibromyalgia, or OCD, you can feel confident that your symptoms are caused by limbic cross-wiring.

How Limbic Cross-Wiring is Treated

The reality is that most people with conditions such as OCD, PTSD, post-viral fatigue, and chronic pain aren’t aware that the root cause of their suffering is limbic cross-wiring. As such, people affected with these disorders will try many different treatments in an effort to recover. The type of treatment depends on the specific condition, but some of the most common treatments include:
  • Medication
  • Psychotherapy
  • Diet changes
  • Nutritional supplements
  • Detoxification
  • Physical therapy
  • Chiropractic care
  • Massage therapy
  • Hypnosis
While people may experience some symptom relief from the above treatments, the results are typically only minor, temporary, and/or unsustainable. This is because these treatments don’t repair the root neurological cause of the dysfunction. Additionally, most, if not all, of the above treatments require frequent visits with a healthcare professional. As you can imagine, this can be very expensive, making these treatments inaccessible to many people due to cost.

How We Approach Limbic Cross-Wiring

Thankfully, there is an effective, permanent solution. Through re-origin, a neuroplasticity-based treatment program, you’ll learn to apply an easy-to-follow, five-step neurocognitive technique to directly retrain the unconscious nervous and immune system responses that are at the root of your symptoms.

re-origin’s approach does not chase or mask symptoms, but rather works to rewire the part of the brain that’s causing the dysfunction (the limbic system), resulting in long-lasting recovery. The program is easy to follow, self-directed, cost-effective, and takes just minutes a day to implement.

Plus, re-origin offers access to a community and coaching specifically geared towards helping people retrain their brains and return to feeling like themselves.

How to Live and Cope with Limbic Cross-Wiring

At re-origin, we believe that nobody should have to live or cope with the effects of limbic cross-wiring. We want you to eliminate your symptoms and conditions and re-establish peace, happiness, and health.

By applying our step-by-step method, you’ll learn to decouple and destroy old neurological associations that may be keeping you stuck and replace them with positive neural pathways that propel you forward. This is done gradually with a process called incremental training. With dedication and repetition, you can break free from the shackles of your limbic system impairment and regain the freedom to live life on your terms.

Frequently Asked Questions

Below are answers to a few of the most commonly asked questions about limbic cross-wiring:
The limbic system is responsible for regulating emotions, particularly emotions that play a role in survival[5], such as aggression, fear, and anxiety. As such, the limbic system plays a prominent role in behavior. For example, if your limbic system has been alerted to danger (whether real or imagined), you’ll feel anxiety and fear, which will cause you to take action to protect yourself from whatever danger is present.
Disorders that are associated with the limbic system include:
  • Multiple Chemical Sensitivity
  • Chronic Fatigue Syndrome (CFS/ME)
  • Fibromyalgia
  • Food Sensitivities
  • Chronic Pain
  • Post Traumatic Stress Disorder
  • Anxiety
  • Depression
  • Obsessive-Compulsive Disorder (OCD)
  • Electric Hypersensitivity Syndrome
  • Adrenal Fatigue
  • Post-Viral Fatigue
  • Chronic Post COVID-19 Syndrome (Long Haul COVID)
  • Irritable Bowel Syndrome
  • Mast Cell Activation Syndrome (MCAS)
  • Chronic Lyme Disease
  • Postural Orthostatic Tachycardia Syndrome (POTS)

re-origin can be used to calm the overactive threat response in your limbic system. The techniques we teach you through our program are based on decades of research and development and aim to put an end to your suffering once and for all.

Using repetition, strong emotions, language, imagery, and other specific neurocognitive exercises, you can learn how to communicate a message of safety to your limbic system, which brings it back to a state of balance.

The limbic system is involved in our behavioral and emotional responses, particularly those related to survival. These behaviors include feeding, reproduction, caring for offspring, and fight or flight responses.
The amygdala is a small, almond-shaped structure in the limbic system that drives the fight or flight response. The amygdala plays a key role[6] in how humans assess and respond to environmental threats and challenges by evaluating the emotional importance of sensory information and triggering an appropriate response.
The brain structures that constitute the limbic system[1] include the cingulate gyrus, parahippocampal gyrus, dentate gyrus, hippocampus, subicular complex, amygdala, septal area, and hypothalamus.

A Final Word from re-origin

Regardless of what stressors or traumas led to your symptoms and conditions, you can recover by correcting the limbic cross-wiring that’s at the root of your suffering. In fact, just by reading this article, you’ve already started the process of retraining your brain! No one should have to live with a limbic system impairment—and thankfully, you don’t have to. With our proprietary neuroplasticity training, you can change your neural pathways and step into a life free from symptoms and full of happiness and well-being. Get started with the re-origin neuroplasticity training program today.


  1. Rajmohan, V., & Mohandas, E. (2007). The limbic system. Indian journal of psychiatry, 49(2), 132–139. Available from:
  2. Bremner, J. D., Elzinga, B., Schmahl, C., & Vermetten, E. (2008). Structural and functional plasticity of the human brain in posttraumatic stress disorder. Progress in brain research, 167, 171–186.
  3. Bremner J. D. (2006). Traumatic stress: effects on the brain. Dialogues in clinical neuroscience, 8(4), 445–461. Available from:
  4. Kays, J. L., Hurley, R. A., & Taber, K. H. (2012). The Dynamic Brain: Neuroplasticity and Mental Health. The Journal of Neuropsychiatry and Clinical Neurosciences, 24(2), 118–124. Available From:
  5. Sokolowski, K., & Corbin, J. G. (2012). Wired for behaviors: from development to function of innate limbic system circuitry. Frontiers in molecular neuroscience, 5, 55. Available from:
  6. Baxter, M. G., & Croxson, P. L. (2012). Facing the role of the amygdala in emotional information processing. Proceedings of the National Academy of Sciences, 109(52), 21180–21181. Available From: